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The consequence of the immunodeficiency is an overwhelming the likelihood of infection and also to the graft-vs-host reaction. The latter occurs when any histo-incompatible tissue from an immuno-competent donor is infused in the immunodeficient recipient. Due to its immunodeficiency, one's body struggles to reject the foreign incompatible tissue. Therefore, the antigenic donor cells attack the host's tissues. The graft-vs-host reaction is a serious complication inside only known strategy for SCID, bone marrow transplant.

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